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KMID : 0371620080230010045
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Journal of Wonkwang Medical Science
2008 Volume.23 No. 1 p.45 ~ p.54
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The Serum HBV DNA level is the Most Important Indicator of Histologic Severity in HBeAg Negative Chronic HBV Carriers
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Cho Eun-Young
Choi Chang-Soo
Kim Tae-Hyeon
Sohn Young-Woo
Cho Ji-Hyun
Moon Hyung-Bae
Shin Sae-Ron
Kim Haak-Cheol
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Abstract
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Background & Aims: Although hepatitis Be Antigen(HBeAg) seroconversion to anti-HBe is often associated with remission of liver disease, a considerable portion of HBeAg negative chronic hepatitis B virus(HBV) infected patients still suffer from active liver disease. Precore and core promoter mutation of HBV have been reported in the worldwide but their clinical significance have not been determined. We aimed to study the inter-relationships of clinical parameters such as serum HBV-DNA, serum aminotransferase, intrahepatic expression of hepatitis B core Antigen(HBcAg) and histological activity in the HBeAg negative young chronic HBV carriers and to study the differences of clinical parameter according to precore mutation.
Methods: The study group included 35 young male patients with biopsy-proven chronic hepatitis B(All HBeAg-negative groups).
Results:1. HBV-DNA were positively correlated to serum transaminase, lobular activity, portal activity, fibrosis and grade of intrahepatic HBcAg expression(p＜0.05), but not correlated to periportal activity. 2. Serum AST and ALT were positively correlated with serum HBV-DNA, lobular activity, and grade of cytoplasmic HBcAg expression(p＜0.001). 3. Nt. 1896 mutation(A, A/G) were not correlated with serum HBV-DNA, transaminase, grade and site of intrahepatic HBcAg expression, and histologic activity. Precore mutation of HBeAg negative group had a positive correlation with the number of apparent amino acid substitution(p=0.017).
Conlusion: Activity of hepatitis in HBeAg negative young chronic B viral hepatitis was not affected by precore mutation. However, the level of serum HBV-DNA in HBeAg negative young chronic B viral hepatitis were strongly correlated to liver injury.
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KEYWORD
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HBeAg negative, Liver histology, Hepatic injury, Viral load, Precore mutation Abbreviations, AST (Aspartate aminotransferase), ALT (Alanine aminotransferase)
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